TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2

Protection against lethal influenza with a viral mimic.

Despite countermeasures against influenza virus that prevent (vaccines) and treat (antivirals) infection, this upper respiratory tract human pathogen remains a global health burden, causing both seasonal epidemics and occasional pandemics. More potent and safe new vaccine technologies would contribute significantly to the battle against influenza and other respiratory infections. Using plasmid-...

Broad cross-protection against H5N1 avian influenza virus infection by means of monoclonal antibodies that map to conserved viral epitopes.

BACKGROUND Passive immunization with human H5 antisera or H5-specific monoclonal antibodies (MAbs) has potential as an effective treatment for acute H5N1 influenza virus infection, but its efficacy against antigenically diverse H5N1 viruses is unconfirmed. METHODS Cross-protection against antigenically diverse H5N1 strains with H5-specific MAbs, generated by successive immunization of antigen...

Respiratory protection against influenza.

Apoptosis-Dependent Phagocytosis Protection of Insects against Viral Infection

Protection of mice against viral infection by Corynebacterium parvum and Bordetella pertussis.

Mice could be significantly protected against infection with herpes simplex virus (HSV) by i.p. or i.v. injection of killed Corynebacterium parvum 7 days before infection. This protection was seen in inbred strains of mice with a different degree of sensitivity to HSV and after both i.p. and i.v. infection. Resistant mice immunosuppressed by X-irradiation and showing an increased susceptibility...